IMR Press / CEOG / Volume 39 / Issue 3 / pii/1630480831280-1938672920

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Modified repeated intracyclic clomiphene citrate therapy after conventional clomiphene therapy
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1 Department of Obstetrics and Gynecology, Kohseichuo General Hospital, Tokyo (Japan)
Clin. Exp. Obstet. Gynecol. 2012, 39(3), 317–320;
Published: 10 September 2012
Abstract

Purpose of investigation: We compared modified repeated intracyclic clomiphene citrate therapy (RICCT) to gonadotropin therapy to determine whether this modified regimen was an effective alternative after conventional clomiphene therapy. Methods: Patients with ovulation disorder received treatment with modified RICCT and gonadotropin, and ovulation, pregnancy, total drug cost, and adverse effects were compared. Results: Among a total of 16 patients, 14 successfully ovulated after modified RICCT and 11 ovulated after gonadotropin therapy; two did not respond to either therapy. The total drug cost was US $36.3 ± 17.9 for modified RICCT, which was significantly lower than the cost of gonadotropin therapy, US $213.9 ± 100.4 (p = 0.0001). Conclusions: Because modified RICCT does not require the discomfort of daily injection and has excellent ovulation-inducing effects, it is a useful treatment after conventional clomiphene therapy.
Keywords
Clomiphene citrate
Gonadotropin
Infertility
Ovulation disorder
Multiple pregnancy
Polycystic ovary syndrome
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