Purpose of investigation: We studied 20 cases of transumbilical single-port laparoscopic hysterectomy (TSPLH) to evaluate the feasibility and safety of the TSPLH. Methods: Perioperative items and complications were observed: mean operation time, blood loss, gas pass time, out of bed activity time, postoperative analgesic rate, pain perception by visual analogue score (VAS), port site infection, hospital stay, postoperative fever rate and patient satisfaction score were measured. Results: All procedures were performed successfully, and no case was transferred to 4-port laparoscopic hysterectomy (LH). No postoperative complication occurred during the period of two month follow-up. Conclusion: TSPLH is a feasible and safe method for hysterectomy, although it may be little more time consuming. Nonetheless, it is welcomed by patients who are more concerned about cosmetic outcomes. Future studies are needed to improve the instruments to shorten the surgery time and confirm its advantages.