IMR Press / CEOG / Volume 39 / Issue 2 / pii/1630475543716-1684785626

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay
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1 Department of Obstetrics, Sao Paulo Federal University, School of Medicine (UNIFESP-EPM), São Paulo (SP)
2 Department of Obstetrics, Sao Paulo University, Faculty of Medicine (FMUSP), São Paulo (SP)
3 Department of Internal Medicine, School of Medicine, Jose do Rosario Vellano University, Alfenas (MG)
4 Department. of Obstetrics and Pediatrics, ABC Medical Foundation (FUABC), São Paulo (SP) (Brazil)
Clin. Exp. Obstet. Gynecol. 2012, 39(2), 205–208;
Published: 10 June 2012
Abstract

Purpose: To evaluate the effects at term of a highly active antiretroviral drug association when administered for the whole period of rat pregnancy. Methods: Forty pregnant rats weighing about 200 g were randomly divided into four groups: a control group (Ctr = drug vehicle control, n = 10) and three experimental groups, which were treated with an oral solution of zidovudine-stavudine (Exp1x = 10/1 mg/kg b.w., n = 10; Exp3x = 30/3 mg/kg b.w., n = 10; Exp9x = 90/9 mg/kg b.w., n = 10) from “day 0” up to the 20th day of pregnancy. Maternal body weights were recorded at the start of the experiment and on the 7th, 14th and 20th day thereafter. At term (20th day) the rats were anesthetized and submitted to hysterotomy. Implantations, reabsorptions, living fetuses, placentae and intrauterine deaths were looked for and recorded. The collected fetuses and placentae were weighed and the concepts were examined by a stereoscopic microscope looking for external malformations. Results: No significant alterations due to the antiretroviral drug treatment could be detected regarding the number of implantations, fetuses, placentae, absorptions and malformations nor regarding maternal and fetal mortality. Conclusions: Administration of the association zidovudine/stavudine for the whole period of rat pregnancy did not interfere with the maternal, fetal and placental weight gain as well as abnormalities detectable by the employed methodology.
Keywords
Rat
Pregnancy
Zidovudine
Stavudine
Adverse effects
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