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Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Editorial
Choosing the right stimulation protocol for in vitro fertilization-embryo transfer in poor，normal, and hyper-responders
J. H. Check1,*, B. Slovis1
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1
The University of Medicine and Dentistry of New Jersey,Robert Wood Johnson Medical School at Camden Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology Division of Reproductive Endocrinology & Infertility, Camden, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2011, 38(4), 313–317;
Published: 10 December 2011
Abstract
Purpose: To describe the advantages of low-dose stimulation for poor responders, the pros and cons of low dose vs high dose stimulation for normal responders and multiple strategies for hyper-responders especially to reduce the risk of the ovarian hyperstimulation protocol. Methods: Various strategies are described for these three types of responders. Results: Poor responders do best with mild stimulation protocols. Conventional stimulation protocols for normal responders have the advantage of providing embryos for future embryo transfers assuming the TVF center has a good cryopreservation program. Mild stimulation protocols save money for normal responders. There are many strategies for hyper-responders to prevent ovarian hyperstimulation syndrome including mild stimulation, high LHFSH ratio for stimulation combination, GinRH agonist instead of hCG and using clomiphene citrate or aromatase imhibitors. Conclusions: Itis important to choose the right protocol for a given patient. An infertile couple can often help in making the decision.
Keywords
Mild ovarian hyperstimulation
Poor responders
Hyper-responders
In vitro fertilization
Cryopreservation