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Serum adiponectin levels are significantly reduced during the second half of normal pregnancy
1 The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2011, 38(3), 211–213;
Published: 10 September 2011
Purpose: To demonstrate the physiologic changes in adiponectin levels during the first vs second half of pregnancy. Methods: Sixty-six females with uncomplicated pregnancies and normal pre-gestational BMI had serum adiponectin levels obtained at various gestational ages. Thirty-one samples were obtained during the first half of their pregnancy vs 35 in the second half. Thirty-three healthy non-pregnant females with comparable ages and BMI were controls. Results: Mean adiponectin levels were 9.55 μg/dl (95% CI 8.2-10.77) vs 9.48 μg/dl (95% CI 8.44-10.66) in the control group in the first half of pregnancy (p = NS). We noted a 21% reduction in mean adiponectin levels (7.51 μg/dl) during the second half of pregnancy (p = 0.03) compared to the first half of pregnancy. Conclusion: Early pregnancy does not affect adiponectin levels. However, there is a significant reduction in adiponectin levels during the second half of pregnancy.