IMR Press / CEOG / Volume 38 / Issue 3 / pii/1630542835032-2036455192

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Successful pregnancy following in vitro fertilization embryo transfer in a 46-year-old woman with diminished oocyte reserve as evidenced by a high day 3 serum estradiol
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1 The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2011, 38(3), 209–210;
Published: 10 September 2011
Abstract

Purpose: To establish a precedent that a successful pregnancy is possible following in vitro fertilization-embryo transfer (IVFET) even in a 46-year-old woman with diminished egg reserve. Methods: Mild ovarian stimulation was used to stimulate multiple follicles in a woman whose diminished oocyte reserve was manifested by elevated day 3 serum estradiol and top normal serum follicle stimulating hormone (FSH). Results: She conceived on her third IVF-ET attempt. She delivered a healthy full term baby girl. Conclusions: This is believed to be the first case report of a successful pregnancy in a woman of this advanced age with diminished oocyte reserve using her own oocytes. It establishes a precedent showing others in similar circumstances that a pregnancy is at least possible though unlikely.
Keywords
Diminished ovarian reserve
Live deliveries
Advanced reproductive age
In vitro fertilization-embryo transfer
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