IMR Press / CEOG / Volume 38 / Issue 3 / pii/1630542832438-1138446538

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Editorial
The importance of sonographic endometrial parameters in influencing success following embryo transfer in the modern era and therapeutic options - Part 1: the importance of late proliferative phase endometrial thickness
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1 The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology Division of Reproductive Endocrinology & Infertility, Camden, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2011, 38(3), 197–200;
Published: 10 September 2011
Abstract

Purpose: To evaluate the importance in the modern era of either too thin or too thick of an endometrium in the late proliferative phase on success following embryo transfer. Methods: Pregnancy rates following fresh embryo transfer in cycles using controlled ovarian hyperstimulation and following donor egg or frozen embryo transfers using artificial estrogen-replaced cycles according to endometrial thickness were determined. Results: A thin endometrium has a negative impact on success following embryo transfer but improvement in IVF technology makes this confounding variable much less important than in the early days of IVF. Too thick of an endometrium does not seem to negatively impact success. Conclusions: Treatment options, e.g., low-dose aspirin, sildenafil or vaginal estradiol are of marginal value in improving endometrial thickness or outcome. For those with a good frozen embryo program the best option may be to cryopreserve all embryos and transfer in a subsequent graduated estrogen/progesterone replacement cycle.
Keywords
Late proliferative active phase
Endometrial thickness
Embryo transfer
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