Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Cite this article
Comparison of single versus multiple courses of antenatal betamethasone in patients with threatened preterm labor
N. Bontis1, D. Vavilis1, D. Tsolakidis1,*, D.G. Goulis1, P. Tzevelekis1, D. Kellartzis1, B.C. Tarlatzis1
1 First Department of Obstetrics and Gynaecology, “Papageorgiou” General Hospital, Aristotle University of Thessaloniki (Greece)
Clin. Exp. Obstet. Gynecol. 2011, 38(2), 165–167;
Published: 10 June 2011
Purpose of investigation: To compare single versus multiple courses of antenatal betamethasone administration with regards to the morbidity and mortality of preterm neonates. Methods: One-hundred and twenty-two women with threatened preterm labor were allocated to three different betamethasone schedules: 1) two doses of betamethasone 1 2 mg, intramuscularly, 24 hours apart (standard treatment) (n = 41); 2) standard treatment plus a third dose of 12 mg after seven days (n = 41); and, 3) standard treatment plus one dose of 12 mg every seven days until delivery (n = 40). Neonatal morbidity and mortality as well as maternal morbidity were evaluated. Results: Neonatal parameters, such as frequency of respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis, sepsis and neonatal mortality were not significantly different among the three groups for both singleton and multiple pregnancies. Similarly, maternal parameters were not significantly different among the three groups. Conclusion: The administration of multiple betamethasone courses in threatened preterm labor is not superior to single courses with regards to neonatal morbidity and mortality, as well as to maternal morbidity.