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Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
Anti-millerian hormone is the best predictor of poor response in ICSI cycles of patients with endometriosis
B. Ramalho de Carvalho1,*, A.C. Japur de Sa Rosa-e-Silva1, J.C. Rosa-e-Silva1, R.M. dos Reis1, R.A. Ferriani1, M.F. Silva de Sa1
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1
Sector of Human Reproduction, Department of Gynecology and Obstrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo (Brazil)
Clin. Exp. Obstet. Gynecol. 2011, 38(2), 119–122;
Published: 10 June 2011
Abstract
Purpose: To correlate ovarian reserve (OR) markers with response in assisted reproduction techniques (ART) and determine their ability to predict poor response among patients with endometriosis (EDT). Methods: We evaluated ART cycles of 27 women with EDT and 50 with exclusive male factor. Basal follicle stimulating hormone (FSH) and anti-millerian hormone (AMH) levels were determined. Ovarian response to gonadotropin stimulation was assessed and correlation coefficients calculated between the variables and reserve markers. Areas under the curve (AUC) determined ability of tests to predict poor response. Results: AMH was signifi- cantly correlated with response in both groups and it was the only marker with significant discriminative capacity to predict poor response among EDT (AUC = 0.842; 95% CI: 0.651-0.952) and control group (AUC = 0.869; 95% CI: 0.743-0.947). Conclusion: Infertile patients with endometriosis can benefit from the pre-therapeutic assessment of OR markers. However, regardless of disease presence, only AMH predicts poor response to stimulus.
Keywords
Ovarian Reserve
Endometriosis
Assisted reproduction
Follicle-stimulating hormone
Anti-millerian hormone
Infertility