IMR Press / CEOG / Volume 37 / Issue 3 / pii/1630630228513-390765929

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Evaluation of serum levels of interleukin-10, interleukin-11 and leukemia inhibitory factor in differentiation of eutopic and tubal ectopic pregnancies
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1 Department of Obstetrics and Gynecology, Istanbul University, Istanbul Faculty of Medicine, Capa, Istanbul
2 Department of Microbiology, Division of Virology and Basic Immunology
3 Department of Biochemistry, Istanbul University, Istanbul Faculty of Medicine, Capa, Istanbul (Turkey)
Clin. Exp. Obstet. Gynecol. 2010, 37(3), 217–220;
Published: 10 September 2010
Abstract

Purpose of study: To investigate whether serum levels of leukemia inhibitory factor (LIF), interleukin 10 (IL-10) and interleukin 11 (IL-11) are different in reference to the site of implantation. Methods: Seventeen patients with laparoscopic diagnoses of tubal ectopic pregnancy (EP) and 19 patients with intrauterine pregnancy delivering healthy term neonates (IUP) were prospectively evaluated for LIF, IL-10 and IL-11 levels. The data were compared by using the Student’s t-test, chi-square test, Kruskal-Wallis and the Mann-Whitney U test with Bonferroni’s correction (p < 0.05) as appropriate. Results: A statistically significant difference was observed in serum LIF levels between the EP and IUP groups (p = 0.002). Ranges of LIF were 15-300 and 70-1200 ng/mL for the IUP and EP groups, respectively. There were no significant differences between groups in terms of IL-10 and IL-11 levels. Conclusion: LIF, but not IL-10 or IL-11, levels may be increased in early tubal ectopic pregnancies when compared to normal intrauterine pregnancies.
Keywords
Cytokines
Ectopic pregnancy
Fallopian tube
Interleukin 10 (IL-10)
Interleukin 11 (IL-11)
Leukemia inhibitory factor (LIF)
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