IMR Press / CEOG / Volume 37 / Issue 2 / pii/1630630037387-1388720897

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Successful treatment of a female with chronic pseudo-intestinal obstruction with sympathomimetic amines and thyroid hormone replacement
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1 The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2010, 37(2), 115–116;
Published: 10 June 2010
Abstract

Purpose: To determine if a defect in sympathomimetic amines, which is a common cause of various undiagnosed pain syndromes in women could be the cause of chronic pseudointestinal obstruction. Furthermore to determine if this life-threatening illness may similarly respond to sympathomimetic amines as in other pain syndromes, e.g., pelvic pain and interstitial cystitis. Method: A 23-year-old, five foot, female with chronic pseudointestinal obstruction, who lost 35 pounds down to 75 pounds, was treated with 15 mg dextroamphetamine sulfate and 50 μg of L-thyroxin (her TSH thyroid hormone level was markedly suppressed in the face of a slightly low free thyroxin level. Results: Her abdominal pain lessened then completely disappeared within a few weeks. Within one year she gained 25 pounds. Conclusions: Chronic pseudointestinal obstruction is another way idiopathic orthostatic edema (a condition found predominantly in women) may manifest. Similar to other gastrointestinal pain syndromes and pain in other areas, e.g., pelvis, bladder, head and joints, treatment with sympathomimetic amines results in dramatic improvement.
Keywords
Chronic pseudointestinal obstruction
Sympathomimetic amines
Orthostatic edema
Hypothalamic hypothyroidism
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