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Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
A novel method to assess the effect of uterine senescence by comparing pregnancy outcome in younger donors vs older recipients who are sharing a common pool of oocytes
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The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2010, 37(2), 97–98;
Published: 10 June 2010
Abstract
Purpose: To evaluate uterine senescence by comparing pregnancy rates in older recipients vs their younger donors who were actually trying to conceive themselves. Methods: A retrospective analysis comparing clinical and delivered pregnancy rates in all infertile donors ≤ age 35 sharing their eggs with a recipient age ≥ 40 over a 6-year time span. These parameters were also evaluated in the first frozen embryo transfer from these couples (if they had one). Results: The clinical and delivered pregnancy rates were similar in younger donors vs older recipients following fresh embryo transfer. There was a non-significant trend for lower implantation rates in the younger donors. No differences were found when comparing frozen embryo transfers. Conclusions: These data support conclusions that the uterus of women ≥ 40 does not inhibit embryo implantation.
Keywords
Uterine senescence
Donor oocytes
Frozen embryos