IMR Press / CEOG / Volume 37 / Issue 1 / pii/1630629611512-247839281

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Editorial
Misoprostol for second trimester abortion in women with prior uterine incisions
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1 Obstetrics and Gynecology Department, “Tzaneio” General State Hospital, Piraeus
2 Obstetrics and Gynecology Department, “G. Chatzikosta” General State Hospital, Ioannina (Greece)
Clin. Exp. Obstet. Gynecol. 2010, 37(1), 10–12;
Published: 10 March 2010

Purpose: Termination of pregnancy in the second trimester with misoprostol is safe and effective, but there is very limited published experience of its use in women with one or more previous cesarean sections. Uterine rupture might occur when misoprostol and oxytocin are used for pregnancy termination at the second trimester in women with previous uterine scars. In the English literature there are some case-series of studied women with a history of previous cesarean sections, in which misoprostol was used for second trimester termination of pregnancy. However, many different protocols have been used with different doses of misoprostol and different intervals between doses and it is difficult to draw definite conclusions. Therefore, the decision to attempt pregnancy termination in the second trimester in cases with previous uterine scar should be made on a case-by-case basis, after consideration of the number of previous cesarean sections and gestational age, and careful labor monitoring of these patients.
Pregnancy termination
Second trimester
Uterine rupture
Cesarean section
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