IMR Press / CEOG / Volume 36 / Issue 1 / pii/1630635161810-1693373874

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Serological testing for celiac disease in women with endometriosis. A pilot study
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1 Sector of Human Reproduction, Department of Gynecology and Obstetrics
2 Department of Puericulture and Pediatrics Faculty of Medicine of Ribeirão Preto, University of São Paulo, SP (Brazil)
Clin. Exp. Obstet. Gynecol. 2009, 36(1), 23–25;
Published: 10 March 2009
Abstract

Purpose of investigation: Celiac disease (CD) involves immunologically mediated intestinal damage with consequent micronutrient malabsorption and varied clinical manifestations, and there is a controversial association with infertility. The objective of the present study was to determine the presence of CD in a population of infertile women with endometriosis. Methods: A total of 120 women with a diagnosis of endometriosis confirmed by laparoscopy (study group) and 1,500 healthy female donors aged 18 to 45 years were tested for CD by the determination of IgA-transglutaminase antibody against human tissue transglutaminase (t-TGA) and anti-endomysium (anti-EMA) antibodies. Results: Nine of the 120 women in the study group were anti-tTGA positive and five of them were also anti-EMA positive. Four of these five patients were submitted to intestinal biopsy which revealed CD in three cases (2.5% prevalence). The overall CD prevalence among the population control group was 1:136 women (0.66%). Conclusion: This is the first study reporting the prevalence of CD among women with endometriosis, showing that CD is common in this population group (2.5%) and may be clinically relevant.
Keywords
Celiac disease
Endometriosis
Infertility
Serologic screening
Pelvic pain
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