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Serological testing for celiac disease in women with endometriosis. A pilot study
F.M. Aguiar1, S.B. Castanheira Melo2, L. Carvalho Galvão2, J.C. Rosa-e-Silva1, R.M. dos Reis1, R.A. Ferriani1,*
1 Sector of Human Reproduction, Department of Gynecology and Obstetrics
2 Department of Puericulture and Pediatrics Faculty of Medicine of Ribeirão Preto, University of São Paulo, SP (Brazil)
Clin. Exp. Obstet. Gynecol. 2009, 36(1), 23–25;
Published: 10 March 2009
Purpose of investigation: Celiac disease (CD) involves immunologically mediated intestinal damage with consequent micronutrient malabsorption and varied clinical manifestations, and there is a controversial association with infertility. The objective of the present study was to determine the presence of CD in a population of infertile women with endometriosis. Methods: A total of 120 women with a diagnosis of endometriosis confirmed by laparoscopy (study group) and 1,500 healthy female donors aged 18 to 45 years were tested for CD by the determination of IgA-transglutaminase antibody against human tissue transglutaminase (t-TGA) and anti-endomysium (anti-EMA) antibodies. Results: Nine of the 120 women in the study group were anti-tTGA positive and five of them were also anti-EMA positive. Four of these five patients were submitted to intestinal biopsy which revealed CD in three cases (2.5% prevalence). The overall CD prevalence among the population control group was 1:136 women (0.66%). Conclusion: This is the first study reporting the prevalence of CD among women with endometriosis, showing that CD is common in this population group (2.5%) and may be clinically relevant.