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Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
The possible influence of increased body mass index on the clinical efficacy of standard human chorionic gonadotropin dosage
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1
Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, and Ben Gurion University School of Medicine, Beer Sheva, Israel, and 1Department of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, and
1
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv (Israel)
Clin. Exp. Obstet. Gynecol. 2009, 36(1), 20–22;
Published: 10 March 2009
Abstract
Objectives: To evaluate whether the efficacy of standard (10,000 IU) hCG dosage is BMI dependent. Patients & Methods: During the study period, body mass index (BMI) was recorded in 261 consecutive women enrolled in our ICSI program. Women in the 90th BMI percentile were compared with those in the 10th percentile. The number and percent of mature metaphase-II (M-II) oocytes were considered as the outcome measure. Results: Mean BMI of the 10th and 90th percentile groups were 18.2 ± 0.7 kg/m2 (n = 26) and 32.8 ± 2.2 kg/m2 (n = 27), respectively. There were no differences between the groups in mean patients age, number of gonadotropin ampoules used, mean number of oocytes retrieved or the number and percentage of mature M-II oocytes. Conclusions: Standard (10,000 IU) hCG dosage is adequate to induce final oocyte maturation in IVF patients regardless of their BMI. This may imply that this hCG dosage is much higher than the dosage that is actually required.
Keywords
BMI
ART
ICSI
hCG
M-II oocyte