IMR Press / CEOG / Volume 35 / Issue 3 / pii/1630638710794-1788304842

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Inherited thrombophilia screening in Greek women with recurrent fetal loss
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1 Department of Internal Medicine, Division of Hematology, 2Department of Obstetrics and Gynecology, University of Patras, Medical School, Rion (Greece)
Clin. Exp. Obstet. Gynecol. 2008, 35(3), 172–174;
Published: 10 September 2008
Abstract

Objective: The present study was designed to determine the prevalence of factor V Leiden (FVL), prothrombin gene G20210A (PTG) and methylenetetrahydrofolate reductase (MTHFR C677T) mutations in women from South-Western Greece with recurrent fetal loss (RFL) and negative personal thromboembolic history. Materials and Methods: 212 women with RFL and 181 women with at least two pregnancies with normal outcome and no history of pregnancy loss were investigated for the commonest thrombophilic mutations (FVL, PTG, MTHFR C677T). Comparisons between groups were performed by Pearson’s chi-square test and odd ratios were calculated. Results: An abnormal genotype was detected in 49 women of the study group (23.1%) and in 41 women of the control group (22.6%). Conclusion: Inherited thrombophilia screening is not indicated as an initial approach in Greek women with RFL and negative personal thromboembolic history.
Keywords
First trimester recurrent fetal loss
Factor V Leiden
Prothrombin G20210A
MTHFR C677T
Molecular thrombophilic testing
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