IMR Press / CEOG / Volume 34 / Issue 3 / pii/2007037

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.


Ovulation defects despite regular menses: part III

Show Less
1 The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2007, 34(3), 133–136;
Published: 10 September 2007

Objective: To describe subtle ovulatory defects that can contribute to infertility and/or miscarriage despite regular menses with appar­ent ovulation. Methods: By using follicular maturation studies and measurement of serum estradiol, progesterone, and LH certain imper­fections in the ovulatory process can be ascertained. Results: Careful evaluation of follicular maturation was able to determine infer­tility factors, e. g., premature luteinization, luteinized unruptured follicle syndrome, and luteal phase defects. Effective treatment agents include follicular maturing drugs and gonadotropin releasing hormone antagonists in the follicular phase, human chorionic gonadotropins and leuprolide acetate at time of peak follicular maturation and progesterone in the luteal phase. Conclusions: Proges­terone supplementation alone is more effective than follicle maturing drugs in women with luteal phase defects with mature follicles. Small doses of follicle stimulating hormone in the late follicular phase is most effective for luteal phase deficiency associated with immature follicles. Sometimes leuprolide acetate can allow egg release when hCG has failed. 

Regular menses
Luteal phase defect
Premature luteinization
Luteinized unruptured follicle syndrome
Back to top