IMR Press / CEOG / Volume 34 / Issue 2 / pii/2007025

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research

Effects of micronized purified flavonoid fraction (Daflon) on pelvic pain in women with laparoscopically diagnosed pelvic congestion syndrome: a randomized crossover trial

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1 Departments of Obstetrics and Gynecology, Akdeniz University, Antalya (Turkey)
2 Departments of Obstetrics and Gynecology, Inonu University, School of Medicine, Malatya (Turkey)
Clin. Exp. Obstet. Gynecol. 2007, 34(2), 96–98;
Published: 10 June 2007
Abstract

Background: We evaluated the effects of daflon, a venomimetic agent that regulates the circulatory tonus of the venous system, on pelvic pain and investigated the role of enlarged veins in the pathophysiology of pelvic congestion syndrome. Methods: Twenty women (age 28-35 yrs) with chronic pelvic pain were diagnosed with the syndrome at laparoscopy. They all had prominent broad ligaments and ovarian veins without other pathologies such as endometriosis to explain the etiology of pelvic pain. Ten women were randomized in a fashion to receive 500 mg of Daflon twice/daily for six months, and ten a vitamin pill for placebo effect; they were crossed over for another six months. Results: At the end of the third month, the frequency and severity of pelvic symptoms began to decrease with daflon compared with the pretreatment and vitamin arm. The mean scores were significantly less at the end of six months, respectively, p < 0.05. Conclusions: Pharmacologic enhancement of venous tonus may restore pelvic circulation and relieve pelvic symptomatology.

Keywords
Pelvic congestion
Daflon
Chronic pelvic pain
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