IMR Press / CEOG / Volume 33 / Issue 4 / pii/2006059

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research

Combined administration of misoprostol in the first and second trimester missed abortion cases

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1 Zeynep Kamil Women and Children’s Education and Research Hospital, Istanbul (Turkey)
Clin. Exp. Obstet. Gynecol. 2006, 33(4), 226–228;
Published: 10 December 2006
Abstract

Objective: We aimed to investigate the effectiveness and adverse effects of combined (vaginal + oral) administration of miso­prostol in missed abortion cases. Material & Methods: 48 missed abortion cases between 8 and 20 weeks of gestation were enrolled in this study. Misoprostol­induced medical abortion was planned; the first dose (200 µg) was administered intravaginally and subsequent doses (200 µg each) orally every following hour. A maximum of six doses (1200 µg) were used. Revision curettage was performed on all subjects who aborted. Results: The mean time interval from the first dose of misoprostol until the abortion was 6.27 ± 3.02 hours. The success rate was 95% for the whole group. We observed misoprostol-related trembling in one patient and fever in two patients. Conclusion: We believe that our low-dose combined misoprostol protocol is a safe, effective and well-tolerated method with minimal adverse effects for the termination of both first and second trimester pregnancy losses.

Keywords
Misoprostol
Missed abortion
Combined administration
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