IMR Press / CEOG / Volume 33 / Issue 3 / pii/2006037

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research

Comparison of GnRH antagonist cycles with and without oral contraceptive pretreatment in potential poor prognosis patients

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1 Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA (USA)
Clin. Exp. Obstet. Gynecol. 2006, 33(3), 145–147;
Published: 10 September 2006
Abstract

Purpose: To evaluate the effect of oral contraceptive pill (OCP) pretreatment in patients undergoing IVF cycles with an antago­nist. Methods: In this retrospective study, 194 cycles of women with diminished ovarian reserve undergoing IVF with a protocol using GnRH antagonists were evaluated. Oral contraceptive pretreatment was used in 146 cycles. Results: Pregnancy rates were the same in both groups. Patients using OCPs required more gonadotropins (5,890 IU) compared to patients not undergoing OCP pretreatment (4,410 IU), Conclusions: Pregnancy outcomes were the same whether or not OCP pretreatment was implemented in poor responders using an antagonist protocol. While OCP pretreatment may help with scheduling flexibility, the higher dose of gonadotropins needed for ovarian stimulation should be considered.

Keywords
IVF
Antagonist
Poor responders
Oral contraceptive pills
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