Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
High frequency of thrombophilic disorders in women with recurrent fetal miscarriage
Objectives: Our purpose was to examine whether genetic thrombophilias are etiological factors for recurrent fetal miscarriage or not. Study Design: We compared the rate of thrombophilic anomalies in women with unexplained recurrent fetal miscarriages to the rate of age-matched women with successful pregnancies as a case-control study. Results: A total of 101 consecutive patients with 102 age-matched controls were included in the study. The rate of Factor V (FV) Leiden mutation, Factor (F) II mutation, protein S, protein C, antithrombin Ill deficiencies and overall thrombophilia in patients with recunrrent fetal loss was significantly higher than the frequencies in control patients. Conclusion: Women with recurrent fetal miscarriages have an increased incidence of thrombophilia. Genetic thrombophilias may be one of the major etiological factors for recurrent abortion and fetal demise.