IMR Press / CEOG / Volume 32 / Issue 4 / pii/2005062

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research

Three successful pregnancies with in vitro fertilization embryo transfer over an eight year time span despite elevated basal serum follicle stimulating hormone levels. Case report

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1 Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2005, 32(4), 217–221;
Published: 10 December 2005
Abstract

Purpose: To demonstrate that elevated basal follicle stimulating hormone (FSH) does not necessarily signify poor quality eggs. Methods: In vitro fertilization-embryo transfer (IVF-ET) performed because of unexplained infertility and male factor related to low hypo-osmotic swelling test. Results: Three live pregnancies following lowering of elevated serum FSH with ethinyl estradiol followed by gonadotropin therapy. The patient had seven attempted oocyte retrievals and five led to ET. Despite markedly elevated basal serum FSH levels she achieved a delivered pregnancy rate of 42.8% per retrieval, 60% per transfer and an implantation rate of 27.2%/embryo transfer. Conclution: This study clearly shows that high serum FSH in a woman of younger reproductive age does not mean egg quality is poor. The case also shows that since ovulation induction was still possible eight years later that the paucity of eggs in younger women is more likely related to a previous catastrophic event that markedly diminished egg reserve but that egg atresia proceeds at the normal rate thereafter.

Keywords
FSH
Hypergonadotropism
In vitro fertilization
Diminished egg reserve
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