Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Predictors of intracytoplasmic sperm injection (ICSI) outcome in couples with and without male factor infertility
Aim: To find out the predictors of ICSI outcome. Methods: Forty-three pregnancies in 100 consecutive ICSI cycles. Results: Every 1,000 pg/mL increase in hCG-day E2 (OR= 0.46, CI: 0.25-0.83, p = 0.01) and 1% decrease in the rate of normal sperm morphology (OR= 0.81, CI: 0.67-0.98, p = 0.03) caused a significant decrease in clinical pregnancy rate and live birth rate (respectively, OR= 0.5, CI: 0.32-0.96, p = 0.03, OR= 0.66, CI: 0.5-0.86, p = 0.002) while every increase in the number of good quality embryos transferred caused a two-time increase in the clinical pregnancy rate (OR = 2.1, CI: 1.2-4, p = 0.01). On the other hand, every increase in the number of four-cell cleavage embryos (OR = 1.02, CI: 1.002-1.04, p = 0.03) and hCG-day endometrial thickness (OR= 1.6, CI: 1.15-2.24, p = 0.005) were found to increase the live birth rate. Implantation rate (m = 8.3 ± 14.6) was significantly lower in cases with leucocytosperrnia (n = 33) compared to cases without leucocytospermia (n = 67, m = 17.4 ± 24.6, p = 0.02). Conclusion: Leucocytospermia, hCG-day E2 level and endometrial thickness, normal sperm morphology, and number of good quality embryos are predictors of implantation, clinical pregnancy and live birth rate following ICSI.