Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Local estrogen replacement therapy in postmenopausal atrophic vaginitis: Efficacy and safety of low dose 17P-estradiol vaginal tablets
Purpose of investigation: To verify the effectiveness and safety of low-dose I 7P-estradiol vaginal tablets in the treatment of the postmenopausal atrophic vaginitis. Patients and methods: 325 postmenopausal women with atrophic vaginitis in estrogenic replacement therapy with 0.025 mg I 7Pestradiol vaginal tablets, one application each day for two weeks, and a single application two times a week for the following 22 weeks (total treatment period: 24 weeks). Results: Most of the women reported an improvement of symptoms just after two weeks and minimal incidence of adverse reactions. No patients showed abnormal endometrial thickness and no one had to interrupt the treatment for abnormal uterine bleeding because of systemic absorption. Conclusion: Low-dose l 7P-estradiol vaginal tablets in the treatment of the postmenopausal atrophic vaginitis constitutes an extremely valid approach in terms of effectiveness and safety.