Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Live delivery following transfer of a single frozen-thawed embryo derived from a 42-year-old woman with marked decreased oocyte reserve
Purpose: To determine if live birth is possible in a woman of older reproductive age and who has markedly decreased oocyte reserve following frozen embryo transfer of an oocyte fertilized by intracytoplasmic sperm injection of testicular sperm. Methods: Ethinyl estradiol followed by ovarian stimulation with gonadotropins was used and a mature follicle was attained. Following oocyte retrieval 34 hours later, intracytoplasmic sperm injection of testicular sperm was performed. The embryo was cryopreserved. Results: A live delivery of a full-term baby ensued. Following subsequent frozen embryo transfer, the baby was diagnosed with Down's syndrome and subsequently died.
Conclusion: This is the first report of a live delivery following frozen embryo transfer in a woman of advanced reproductive age with marked decreased oocyte reserve.