IMR Press / CEOG / Volume 31 / Issue 4 / pii/2004067

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Evaluation of Langerhans’ cells in human papillomavirus­associated squamous intraepithelial lesions of the uterine cervix

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1 Universidade Estadual de Maringd, UEM, Maringd, PR (Brazil)
2 Universidade Federal de Sao Paulo, UNIFESP, Sao Paulo (Brazil)
Clin. Exp. Obstet. Gynecol. 2004, 31(4), 260–262;
Published: 10 December 2004
Abstract

Current research has been evaluating morphological modifications and density of Langerhans’ cells in women with histopatho­logical HPV lesions of the uterine cervix, Fourteen women with subclinical HPV infections underwent clinical, colpocytological colposcopy examinations, and paired biopsies of the uterine cervix. Histopathological, HPV hybrid capture and S-100 immunohistochemical examinations were performed in biopsy specimens. Groupings of viral lesions and normal tissue were analyzed by the Wilcoxon rank-sum test. Langerhans’ cells in the specimens were frequently located in the intermediate and basal layers of the epithelium. A significant reduction of cytoplasmic profiles occurred in viral lesions (144.08 profiles/mm2) when compared to normal tissue (256.27 profiles/mm2) of the epithelium. An inverse modulation occurred in the cytoplasmatic profiles/nuclei ratio with 2.80 in viral lesions and 4.89 in normal tissue of the stroma. A local immunodeficiency based on cytoplasmic changes of Langerhans’ cells has been postulated as a mechanism by which HPV could be involved in the genesis of neoplasia.

Keywords
Langerhans’ cells
Human papillomavirus
Immunity
Uterine cervix
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