IMR Press / CEOG / Volume 31 / Issue 4 / pii/2004066

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Effect of antagonists vs agonists on in vitro fertilization outcome

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1 The University of Medicine and Dentistry New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology,·Division of Reproductive Endocrinology & infertility Camden, NJ (USA)
2 Lehigh Valley Hospital, Department of Obstetrics and Gynecology Allentown, PA (USA)
Clin. Exp. Obstet. Gynecol. 2004, 31(4), 257–259;
Published: 10 December 2004

Purpose: To compare outcome following in vitro fertilization-embryo transfer (IVF-ET) using controlled ovarian hyperstimulation (COH) regimens using either the gonadotropin-releasing hormone (GnRH) agonist leuprolide acetate vs the GnRH antagonist ganirelix. Methods: Women needing IVF for conception were randomly assigned to 300 IU of gonadotropins with ganirelix used in the follicular phase when a follicle with a 14 mm average diameter was attained vs a regimen using leuprolide acetate from the mid-luteal phase of the previous cycle. Results: There were no differences found in clinical, ongoing, delivered pregnancy rates or implantation rates between groups. Conclusions: The use of GnRH antagonists do not seem to reduce IVF outcome compared to using GnRH agonists in COH regimens.

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