IMR Press / CEOG / Volume 31 / Issue 3 / pii/2004047

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research

Outcome of in vitro fertilization-embryo transfer according  to age in poor responders with elevated baseline serum  follicle stimulation hormone using minimal or no  gonadotropin stimulation

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1 The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper/Hospital University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2004, 31(3), 183–184;
Published: 10 September 2004
Abstract

Purpose: To determine whether decreased ovarian reserve or advancing age are more associated with decreased oocyte quality. Methods: Women with baseline serum follicle stimulating hormone (FSH) >12 mIU/mL who demonstrated previous poor response to controlled ovarian hyperstimulation (COH) had oocyte retrieval without gonadotropin stimulation in natural cycles or with minimal stimulation (maximum 75 IU gonadotropins) without agonists or antagonists were evaluated following in vitro fertiliza­tion-embryo transfer. Results: The ongoing/delivered pregnancy rates were 27.3%, 30.8%, 21.7%, and 0.0%, respectively, with a mean of 1.06 embryos per transfer. The implantation rates were 33.3%, 28.6%, 14.7%, and 6.0%. Approximately half of the retrievals resulted in failed fertilization. Conclusion: Using these minimal or no drug COH regimens in a difficult group of women, age was found to be a more adverse infertility factor than elevated serum FSH.

Keywords
Oocyte reserve/quality
Hypergonadotropism
Follicle stimulating hormone
Natural oocyte retrieval
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