Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Preemptive meloxicam for postoperative pain relief after abdominal hysterectomy
Objective: This study was conducted to evaluate the analgesic efficacy of meloxicam in abdominal hysterectomy. Methods: The study population consisted of 52 patients scheduled for total abdominal hysterectomy who were ASA 1 or 2 physical status female. Patients were allocated randomly to receive orally either 15 mg of meloxicam (Group M, n = 27) or placebo (Group P, n = 25) before anesthesia induction. After intravenous administration of 1.5 mg kg-1of tramadol, anesthesia was induced with an intravenous loading dose of 1-2 mg kg-1propofol. Anesthesia was maintained on intravenous infusion of propofol at 6-12 mg kg-1h-1plus tramadol at 1 mg kg-1 h-1, vecuronium, and a 2:1 nitrous oxide-oxygen mixture. Results: The relative propofol consumption was lower in Group M than in Group P, (p < 0.05). The time for analgesic rescue decreased in the order Group M > Group P (p < 0.01). The degree of sedation was similar between the groups (p > 0.05) and the visual analog scores (10-cm scale) and verbal rating scale data differences were present in the first 2 h only (p < 0.05). When sideeffects were evaluated nausea and vomiting were found to be lower in group M than in group P (p < 0.05). Conclusion: Preemptive meloxicam provided better postoperative analgesia than placebo.