Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Activated protein C resistance in preeclampsia
Objective: Recently, hereditary and acquired diseases that lead to thromboembolic events by changing the hemostatic balancehave attracted interest as a cause of preeclampsia. In this study the incidence of activated protein C resistance(APCR) in preeclamptic women was evaluated. Methods: Activated protein C sensitivity ratio (APC-SR) was measured by the modified activated partial thromboplastin time(APTT)method in 19 preeclamptic and 12 healthy pregnant women and 26 normal women as the controls. Results: below the levelsof 2 were accepted as the presence of APCR. Results: Median APC-SR values of 2.12 and 2.0l in preeclamptic and healthy pregnant women, respectively, were found signif-icantly lower than the normal control values of 2.31(p =0.0005, p = 0.001). APCR was detected in 31% of preeclamptic patients, 16.6% of healthy pregnant women and 7.6% of normal controls. Conclusion: APCR was found significantly higher in preeclamptic women and it may play an important role in the pathogenesisof preeclampsia.