Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Influence of angiotensin converting enzyme inhibitors on stable myocardial ischemia in menopausal cardiac patients
Objective: The aim of the study was to investigate the influence of angiotensin converting enzyme inhibitor (Captopril) on stable demand ischemia in menopausal cardiac female patients. Methods: In a prospective non-randomized evaluation of the effect of angiotensin converting enzymes inhibitors (ACE-I) (Captopril) on demand myocardial ischemia, 16 normotensive menopause female patients, mean age of 52 years with stable angina and known coronary artery disease (CAD) but normal left ventricular function, underwent a treadmill exercise test (Bruce Protocol), at baseline (Tl) and one week following (50-75 mg) a daily dose of Captopril (CAPT2). Onset of symptoms, duration of exercise, magnitude of peak ST depression and homodynamic parameters were monitored. Results: Captopril significantly increased the duration of exercise from (467 ± 169 to 536 ± 145 seconds, (p value < 0.02), but with increased peak of ST segment depression (from -1.4 ± 0.6 mm to -1.93 ± 1.2 mm, p value < 0.15). The double product remained unchanged (251 × 103 ± 55 in Tl and 248 x 103 ± 55 in CAPT2; the p value was <0.8. All adverse effects on the treadmill were noted. Conclusion: Although captopril tends to significantly effect prolongation of exercise time, there is no amelioration of the markers of ischemia.