IMR Press / CEOG / Volume 28 / Issue 4 / pii/2001076

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Cigarette smoking and the degree of maturation of the vaginal squamous epithelium in postmenopausal women

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1 Department of Obstetrics and Gynecology, General Regional Hospital of Alexandroupolis (Greece)
2 Department of Cytology, General Regional Hospital of Alexandroupolis, Alexandroupolis (Greece)
Clin. Exp. Obstet. Gynecol. 2001, 28(4), 274–276;
Published: 10 December 2001

To determine the effects of cigarette smoking on vaginal squamous epithelium in postmenopausal women, we studied the vaginal smear patterns of 199 healthy postmenopausal non-smokers and 41 healthy postmenopausal smokers, with a mean age of 56 years. A statistically significant difference to the hazard of smokers was found in the percentage of smears manifesting absence of matu­ration of vaginal squamous cells. A high incidence of atrophic-type vaginal smears in the group of smokers was also found inde­pendent of postmenopausal age. In the group of non-smokers, there was a statistically significant difference between the cytologic patterns of smears of women who were in the early postmenopausal age (<10 years) and those many years after (≥10 years). Finally our data suggest that smokers had an earlier menopause, on average 2.4 years sooner than non-smokers. Cigarette smoking has an effect on vaginal squamous epithelium, but pathophysiology still remains unclarified.

Vaginal maturation
Vaginal smear
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