IMR Press / CEOG / Volume 28 / Issue 3 / pii/2001047

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research

Expression of fibrillar proteins and vimentin in developing chorionic villi is related to fetal maturation

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1 Department of Histology-Embryology, Democritus University of Thrace (Greece)
2 Department of Histology-Embryology, Democritus University of Thrace (Greece)
3 Department of Pathology, Democritus University of Thrace (Greece)
4 Department of Obstetrics & Gynecology, Democritus University of Thrace (Greece)
5 Department of Obstetrics & Gynecology, Regional Hospital of Alexandroupolis (Greece)
6 Department of Surgery, Democritus University of Thrace (Greece)
7 Medical School, Democritus University of Thrace (Greece)
8 Department of Medical Physics, Democritus University of Thrace (Greece)
9 Department of Cytology, Regional Hospital of Alexandroupolis (Greece)
Clin. Exp. Obstet. Gynecol. 2001, 28(3), 171–172;
Published: 10 September 2001
Abstract

Using an immunocytochemical technique, the extracellular matrix components fibronectin, vimentin, laminin and collagen type IV were investigated in human chorionic villi of various stages of development. Fibronectin and laminin were consistently positive throughout embryonic development. Vimentin and collagen type IV were negative in first and second trimester chorionic villi, but became positive in term placentas. With the exception of laminin, all extracellular matrix molecules were detected in the villous stroma and, with the exception of vimentin, they were localized in the basement membranes. Our data suggest that fibronectin and laminin are essential components of the villous structure, while the presence of vimentin and collagen type IV in the chorionic villi should be regarded as an indicator of fetal maturation.

Keywords
Fibrillar proteins
Vimentin
Chorionic villi
Fetal maturation
Laminin
Collagen type IV
Fibronectin
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