Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Maternal/paternal sharing of DQ-Alpha type II histocompatibility antigens not associated with pregnancy outcome following in vitro fertilization (IVF)-embryo transfer (ET)
Purpose: To determine if maternal/paternal sharing of DQ alpha major histocompatibity (MHC) type II antigens is associated with reduced pregnancy and implantation rates following in vitro fertilization-embryo transfer (IVF-ET). Methods: Prospective study with type II MHC DQ alpha alleles detected by polymerase chain reaction (PCR) technology using Perkin Elmer Amyli-type HLA DQ alpha PCR amplification and typing kit. The tests were only performed on patients having their first IVF cycle. Results: No difference was found in clinical pregnancy rates per transfer between those couples sharing DQ alpha 1 alleles and those who did not (43.7% vs 40%). There were no spontaneous abortions in the group sharing DQ alpha 1 alleles. Conclusion: Maternal/paternal sharing of DQ alpha I antigens does not reduce fecundity following IVF-ET.