IMR Press / CEOG / Volume 27 / Issue 3-4 / pii/2000069

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research

Teratogenic effects of propineb on rat skin

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1 Department of Pathology, Diyarbakır (Turkey)
2 Dermatology, Diyarbakır (Turkey)
3 Histology and Embryology, Diyarbakır (Turkey)
4 Anatomy, the Medical Faculty of Dicle University
Clin. Exp. Obstet. Gynecol. 2000, 27(3-4), 235–237;
Published: 10 September 2000
Abstract

The dithiocarbamates are known to cause dermatitis, conjunctivitis, rhinitis, pharyngitis and bronchitis in humans. The experimental group received Propineb (obtained from Bayer) concentrations of 400 ppm in distilled water five days a week (treatment time three weeks) administered orally by gasric pit. Acute oral LDSO for male rats has been found to be 8,500 mg/kg (Worthing, 1983). The control group (n=10) received only distilled water. At ultrasonographical examination, there were no resorbed fetuses or stillborns during or after propineb administration. It can be clearly seen that the body weights of the experimental group of litters are lower than those of the control group (p<0.001). However, the mean length of the experimental litters was identical to the control group of litters (p>0.05). Under microscopical examination, increased keratinization and hyperplasia were observed in the epider­mal cells. 

Keywords
Propineb
Rat
Skin
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