IMR Press / CEOG / Volume 27 / Issue 2 / pii/2000043

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research

Significance of changes in lipid peroxides and antioxidant enzyme activities in pregnant women with preeclampsia and eclampsia

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1 Department of Obstetrics and Gynecology, Dicle University, Diyarbakir (Turkey)
2 Biochemistry, Dicle University, Diyarbakir (Turkey)
3 Internal Medicine, Dicle University, Diyarbakir (Turkey)
4 Physiology, Medical Faculty, Dicle University, Diyarbakir (Turkey)
Clin. Exp. Obstet. Gynecol. 2000, 27(2), 142–146;
Published: 10 June 2000
Abstract

This review addresses the general hypothesis that the pathogenesis of preeclampsia and enclampsia are related to an imbalance of increased oxidative stress and lipid peroxidation coupled with a deficiency of antioxidant protection. Accordingly, this study was initiated to assess total antioxidant status and free-radical activity in preeclampsia and eclampsia. The patients studied were 44 healthy pregnant woman and 45 women with hypertension classified as having preeclarnpsia (n = 27), and eclarnpsia (n = l8). The serum levels of lipid peroxide were significantly increased (p < 0.0001) and antioxidant enzyme activities (superoxide dismutase and gluthathione levels) in erythrocytes were significantly decreased (p < 0.0001) in women with preeclarnpsia and eclarnpsia compared with the controls. The groups of preeclarnpsia and eclarnpsia had similar values of catalase activities as the controls (p > 0.05). There were no correlations between serum levels of lipid peroxide and antioxidant enzyme activities or systolic-diastolic blood pressure of pregnant women with preeclampsia and eclampsia. The mean systolic and diastolic blood pressure, the serum lactatc dehydrogenase (LOH) and aspartate transaminase (AST) levels of preeclamptic and eclamptic women were high, whereas haemoglob in (Hb), Hematocrit (Htc) and platelet levels were lower than those of the control subjects (p < 0.0001). There were no diffe­rences in mean gestational week, whereas the mean age of eclamptic women was lower than that of the other two groups (p < 0.001) The serum levels of Alanin-transaminasis (ALT) and urea in eclamptic women were significantly higher compared with the other two groups (p < 0.0001), whereas creatinin levels were lower than those of the other two groups (p < 0.05). Our findings give support to those few studies considering lipid peroxidation as an important factor in the pathogenesis of preeclampsia and eclampsia. Further studies are needed to clarify the relations between lipid peroxidation and antioxidative function and their pathophysiological significance in preeclampsia and eclampsia.

Keywords
Lipid peroxide
Glutathione
Superoxide dismutase
Catalase
Preeclampsia
Eclampsia
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