IMR Press / CEOG / Volume 26 / Issue 3-4 / pii/1999031

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Effects of conjugated estrogens and progestogen in surgically induced endometriosis in oophorectomized rats

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1 Departments of Gynecology, Universidade Federal de Sao Paulo - Escola Paulista de Medicina (Brazil), Federal University of Sao Paulo, Paulista School of Medicine Sao Paolo (Brazil)
Clin. Exp. Obstet. Gynecol. 1999, 26(3-4), 158–161;
Published: 10 September 1999

This study aimed to verify whether estrogen replacement alone or associated with progesterone promotes the recurrence of expe­rimental endometriosis in oophorectomized rats. The procedure utilized for endometriosis induction was adapted from the one described by Jones (1984). The rats were castrated three weeks after the induction. Hormonal replacement was started 14 days after the castration and was given for 24 days. One group received estrogen alone, another received estrogen associated with medroxiprogesterone acetate, and a last one received placebo. At the end of this study, the animals who received hormonal medication showed recurrence of the disease. This fact was more evident in the group that received estrogen alone. We concluded that estrogen alone leads to recurrence of endometriosis in oophorectomized rats with surgically induced endome­triosis. The association of medroxiprogesterone promotes involutional changes in the implants, and should be added upon the exi­stence of a past history of endometriosis.

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