IMR Press / CEOG / Volume 26 / Issue 1 / pii/1999008

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research

The effect of combined iron therapy (Chemiron®) and single iron therapy on the dexamethasone-estriol reaction test for placenta insufficiency during normal pregnancy

Show Less
1 Senior Lecturer/Consultant, Department of Obstetrics & Gynaecology, College of Medicine, Idi-Araba, Lagos Senior Lecturer, School of Pharmacy, College of Medicine, University of Lagos, Idi-Araba, Lagos
Clin. Exp. Obstet. Gynecol. 1999, 26(1), 27–30;
Published: 10 March 1999
Abstract

Impaired uteroplacental perfusion has been shown to play a role in the pathogenesis of some complicated pregnancies with pla­centa insufficiency. Apart from this, lower oestrogen, magnesium and zinc are found in many of these conditions in the third tri­mester with placenta insufficiency. In this study, we examined the effect of a 4 mg intravenous dexamethasone injection on estriol, since maternal cortisol or synthe­tic corticosteroids cross the placental barrier and inhibit the release of dehydroepiandrostesone sulfate in the fetal adrenals. Dexa­mathasone was found to suppress estriol levels in all groups but a significant difference in suppression was found between the Che­miron - a new combination hematinic - and the control single iron therapy groups. Our preliminary results showed that Chemiron has a protective effect on the development of placenta insufficiency during the third trimester of pregnancy.

Keywords
Combined Iron (Chemiron®)
Single iron
Therapy
Placenta Insufficiency
Dexamethasone Estriol Reaction Test
Share
Back to top