IMR Press / CEOG / Volume 24 / Issue 4 / pii/1997073

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

The effect of tamoxif en on the neonatal development of rat glans penis

Show Less
1 Department of Histology and Embryology, University of Dicle, Diyarbakir - Tiirkiye
2 Department of Pediatric Surgery, University of Dicle, Diyarbakir - Tiirkiye
3 Department of Anatomy - Medical Faculty, University of Dicle, Diyarbakir - Tiirkiye
Clin. Exp. Obstet. Gynecol. 1997, 24(4), 237–239;
Published: 10 December 1997

From the first day of birth to the fifth day, daily subcutaneous 100 µg tamoxifen (Tx) was injected into new-born male rats. The penises that were taken totally were fixated in 10% formaline, and then they were put in paraffin inclusion. The paraffin sections were stained with Hematoxylen-Eosin, Verhoeff and Triple on days 7, 14, 21, 28, 35 and 60. The alterations in the development of glans penis construction were examined. We found that in the glans penis of animals which were given Tx, from the 21st day, the epidermal projections were erased slowly and on the 60th day the epidermal projections and keratinisation completely ceased alto­gether. As a result, the development of epidermal projections in rats which were given tamoxifen in the neonatal period were hindered.

Glans penis
Back to top