IMR Press / CEOG / Volume 24 / Issue 4 / pii/1997064

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Histopathological changes in the vagina of rats treated neonatally with clomiphene citrate

Show Less
1 Dicle University Medical Faculty, Department of Pediatric Surgery (Turkey)
2 Dicle University Medical Faculty, Department of Histology and Embryology (Turkey)
3 Dicle University Medical Faculty, Department of Pharmacology (Turkey)
Clin. Exp. Obstet. Gynecol. 1997, 24(4), 203–205;
Published: 10 December 1997

Clomiphene citrate is a nonsteroid antiestrogen which is widely used in the therapy of receptor-positive estrogen for the induction of ovulation. Clomiphene citrate was given subcutaneously to newly born rats with daily injections of 100 mg/kg for 5 days Changes caused by the clomiphene citrate in vaginas of female rats were investigated at 28 and 35 days. Depending upon the effect of the clomiphene citrate,h istopathological changes such as papillary development at keratinization,i ncrease in vaginal epithelium, and observation of polygonal shaped nodular cells in stroma were considered as important findings. It should be emphasised that clomiphene citrate used for induction of ovulation caused these abnormalities in the vagina of rats.

Clomiphene citrate
Neonatal rat
Histopathological changes
Back to top