IMR Press / CEOG / Volume 24 / Issue 4 / pii/1997063

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Histopathological changes in the uterus of rats treated neonatally with clomiphene citrate

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1 Department of Histology and Embryology, Dicle University Medical Faculty (Turkey)
2 Department of Pediatric Surgery, Dicle University Medical Faculty (Turkey)
3 Department of Pharmacology, Dicle University Medical Faculty (Turkey)
Clin. Exp. Obstet. Gynecol. 1997, 24(4), 200–202;
Published: 10 December 1997

Clomlphene citrate has estrogenic and teratogenic effects on the developmg rat and human fetal genital tract. Clomiphene citrate was given subcutaneously to newly born rats by daily injections of 100 µg/kg and changes caused by clomiphene in female rats were investigated at 28 and 35 days. Depending upon the effect of clomiphene citrate, histopathological changes such as the observation of polygonal shaped nodular cells in the uterus epithelium and presence of erythrocytes in free nature in the stroma were considered as important findings.

Clomiphene citrate
Neonatal rat
Histopathological changes
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