IMR Press / CEOG / Volume 24 / Issue 4 / pii/1997060

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

17-alpha-hydroxyprogesterone caproate and natural progesterone in assisted reproduction: a comparative study

Show Less
1 Physiopathology of Human Reproduction, Papardo Hospital, Messina, Rome
2 2nd Institute of Gynaecology and Obstetrics, University “La Sapienza”, Rome
Clin. Exp. Obstet. Gynecol. 1997, 24(4), 190–192;
Published: 10 December 1997

The use of luteal phase support has been demonstrated in patients undergoing an IYF/ET procedure. This study was designed to compare the absorption and the efficacy of two different luteal supports: 17-alpha-hydroxyprogesterone caproate (Lentogest, AMSA, Italy) and natural Progesterone (Prontogest, AMSA, Italy). A total of 80 patients received luteal supplementation with 50 mg of natural P/day intramuscularly, until β-hCG evaluation. Then, in case of positive β-hCG, patients were randomly dividied into two groups (A and B) in order to compare two different protocols: Group A, 17-OHPc (341 mg once a week) and Group B, natural P (50 mg/day) both intramuscularly and extended for 10-12 weeks. Our study showed that the treatment with 17-OHPc results in a higher percentage of pregnancy rate compared to natural P, but the differences are not statistically significant. Thus, we emphasize that 17-OHPc preparation for better acceptance appears to be the most suitable and comfortable method for luteal phase support.

Back to top