Purpose: To investigate if gynecologic cancer patients have different immune responses. Methods: Immunoglobulin heavy chains (G1m, G3m), Kappa light chains (Km) and allotype and phenotype frequencies were examined in 58 patients with gynecologic cancer (ovarian, cervical, endometrial, vulval, vaginal and uterine sarcoma) and a control group of 26 women. Results: No significant differences were found between the different allotype or phenotype frequencies between the two groups. Conclusions: Our results indicate that Gm and Km allotypes do not represent susceptibility factors for gynecologic cancer in Caucasians.