IMR Press / CEOG / Volume 24 / Issue 2 / pii/1997026

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research

Does postprandial hypersinsulinemia contribute to hyperandrogenism in patients with polycystic ovary syndrome?

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1 3rd Department of Obstetrics and Gynecology, Aristotelian University, Thessaloniki - Greece
Clin. Exp. Obstet. Gynecol. 1997, 24(2), 88–91;
Published: 10 June 1997
Abstract

Twenty patients with polycystic ovarian syndrome and with or without insulin resistance, and 20 healthy women (controls) underwent an oral glucose tolerance test, which resulted in a short duration but significant increase of serum insulin levels. Serum testosterone, androstenedione and dehydroepiandrosterone sulfate levels were estimated before and I80 minutes after administration of 75 gr. dextrose. Our results, three hours after dextrose administration, showed that: (1) serum testosterone levels decreased significartly, (2) serum androstenedione levels decreased but not significantly, and (3) serum dehydroepiandrosterone sulfate levels were not altered. The observation of decreased ovarian androgen levels after induced hyperinsulinemia is very interesting, the explanation. However, is quite difficult. This unexpected ovarian androgen response needs further investigation.

Keywords
Polycystic ovary syndrome
Insulin
Androgens
Oral glycose tolerance test
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