IMR Press / CEOG / Volume 24 / Issue 1 / pii/1997013

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Hemocoagulative pathology and immunological recurrent abortion

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1 3rd Obstetric and Gynaecological Clinic, Second University of the Studies of Naples (Italy)
2 Jmmunopathology Service, Second University of the Studies of Naples (Italy)
Clin. Exp. Obstet. Gynecol. 1997, 24(1), 39–40;
Published: 10 March 1997

To assess the relation between immunological disorders and recurrent abortion, 15 pregnant women with previous unexplained re­current abortivity were submitted to serum screening for antiphospholyeid antibodies syndrome (APA) syndrome. The screening included specific tests for autoimmune diseases (ANA, specific organ antibodies, immune complexes research, etc.), the immunoenzymatic assay (ELISA) for the research of anticardiolipin antibodies (ACA) and the determination of the kaolin coa­gulation time (KCT) through Exener method for lupus anticoagulant (LAC). Nine gravids out of 15 were positive both to LAC and ACA antibodies, two gravids were positive to only ACA antibodies, while four had no antibody reaction. Therefore, whatever the effective mechanism is, it seems ascertained that several cases of unexplained recurrent abortion are rela­ted to APA syndrome. Nowadays the above-mentioned syndrome is successfully treated using corticosteroid immunosuppressors and platelet antiaggre­gators which reduce autoimmune reaction and thrombotic episodes.

Recurrent abortion
Hemocoagulative pathology
APA syndrome
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