IMR Press / CEOG / Volume 23 / Issue 4 / pii/1996042

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research

Long term follow-up of endometriosis after two different therapies (Gestrinone and Buserelin)

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1 Servicio de Obstetricía y Ginecología, Hospital Universitario Príncipe de Asturias
Clin. Exp. Obstet. Gynecol. 1996, 23(4), 198–204;
Published: 10 December 1996
Abstract

Objective: To compare the efficacy, tolerance and recurrence rate of endometriosis after 5-year follow-up of treatment with Gestrinone and Buserelin, respectively. Study design: A prospective study with randomized follow-up of 5 years duration (minimum) for each patient was done. We included 43 cases of endometriosis diagnosed by laparoscopy or laparotomy and treated them with Gestrinone (Group G, n = 25 cases) or Buserelin intranasal spray (Group B, n = 18) for 6 months. Results: General data: Age, height, weight of patients and AFS score of endometriosis were without significant differences in either group. Specific data: A) Global clinical efficacy was good or excellent in 74% (16/25) of group G and in 78% (14/18) of group B without significant differences. B) Global clinical tolerance was good in 50% of the patients in group G and in 0% in group B (p < 0.001). C) Global evaluation after 5-year follow-up showed “success” only for 36% of patients in group G and in 33% in group B (no significant differences), with “failure” in 40% and 33%, respectively (no significant differences). Conclusions: Gestrinone and Buserelin intranasal spray are valid treatments for the remission of endometriosis, with “success”, “failure” and “clinical recurrence” rates similar after a follow-up of 5 years of initial treatment. 2) The most significant androgenic effect of Gestrinone was the presence of acne. Vascular effects were also considered as very undesirable effects according to the comments of patients. On the contrary, the effects of analogs are generally better tolerated.

Keywords
Endometriosis
Analogs of LHRH
Buserelin
Gestrinone
Efficacy
Tolerance
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