Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Triploid partial molar pregnancy and fetal neural tube defect detected through Down's syndrome screening
A third case of triploid partial molar pregnancy with fetal neural tube and abdominal-wall defect, detected through maternal serum alphafetoprotein and hCG screening for Down’s syndrome is reported. A 23-year-old woman had elevated serum alphafetoprotein and hCG levels at routine screening at the 16th week of gestation. Ultrasound examination suggested a fetal neural tube and abdominal-wall defect with thickened placenta. Amniocentesis was performed. A triploid karyotype (69 XXY) was confirmed with standard cytogenetic analysis. Fetal neural tube and abdominal wall defect was confirmed at the autopsy of the fetus. Placental histology was consistent with a hydatiform mole. When serum alphafetoprotein and hCG are elevated, during screening for Down’s syndrome, the possibility of a partial molar pregnancy with fetal malformation should be added to the differential diagnosis