Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Induction of multifollicular growth in patients non responding to clomiphene citrate and gonadotropins or gonadotropins only
Objective: We aimed at inducing multifollicular recruitment in patients with chronic anovulation resistant to Clomiphene Citrate (CC) and/or exogenous gonadotropins. Design: At the II Department of Obstetrics and Gynecology we treated our patients with exogenous gonadotropins and concomitant endogenous gonadotropin suppression obtained by the use of a GnRH analog (Buserelin). Patients: We studied 14 patients with chronic anovulation due to either hypothalamic dysfunction or polycystic ovarian syndrome. Measurements: We monitored the follicular growth ultrasonographically from the eighth day of the menstrual cycle, and assessed E, and LH daily dosage from the tenth day. Results: With this protocol we obtained 2 or 3 and progesterone increase took place only after human chorionica gonadotropins administration.