IMR Press / CEOG / Volume 21 / Issue 3 / pii/1994032

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research

Therapeutic prospects of natural alpha interferon from normal human leucocytes in the treatment of genital condylomata in HIV positive women

Show Less
1 University of Naples, Faculty of Medicine and Surgery Gynaecology and Obstetrics Department Virology Special Service
2 University of Naples, Naples, Faculty of Medicine and Surgery Gynecology and Obstetrics Department
Clin. Exp. Obstet. Gynecol. 1994, 21(3), 173–176;
Published: 10 September 1994
Abstract

Various Authors underline that HIV positive women have a higher CIN incidence and a higher prevalence of HPV. HIV could act as cofactor in the proliferation of HPV manifestation, because of a hypothetical deficit of local immunity. 5 HIV positive patients have been examined: 3 of them presenting vulvocondylomas and/or VIN were treated with 1.000.000 IU alpha IFNn three times a week for three weeks. 2 of them presenting CIN and/or HPV were treated with a two-phase therapy: A) Induction therapy: 3.000.000 IU 3 times a week for three cycles. B) Maintenance therapy: 1.000.000 IU 3 times a week for three months. IFN was the primary treatment for viral lesions, even though an improvement of prognostic indices (CD4, CD4/CDB, 2M), has shown its usefulness in association or in alternative to AZT.

Keywords
HPV
HIV
Interferon
Share
Back to top