Announcements
Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
A randomized comparative study for the clinical evaluation of hormone replacement by transdermal and oral routes
F. Polvani1, L. Zichella1, A. Bocci1, F. Bottiglioni1, G. Cagnazzo1, C. Campagnoli1, L. Carenza1, S. Cianci1, V. Danesino1, L. De Cecco1, P. Fioretti1, A. R. Genazzani1, G. B. Massi1, G. Mollica1, U. Montemagno1, A. Onnis1, N. Pasetto1, P.L. Carriero1
Show Less
1
Dipartimento Medico “Ciba Geigy” S.p.A. Origgio (Varese)
Clin. Exp. Obstet. Gynecol. 1991, 18(4), 207–213;
Published: 10 December 1991
Abstract
During a six-month randomized study involving 460 post-menopausal women, transdermal estradiol has proved to be as effective as oral conjugated equine estrogens in the control of menopausal symptoms and to produce similar estrogenic effects on the endometrium. The group of patients treated with transdermal estradiol showed better compliance and had fewer drop-outs. Moreover, the quality and duration of menstrual bleeding were considered more physiological in the transdermal estradiol group than in the orally treated patients. The trial was carried out with the co-operation of 17 Italian University Centres, under the supervision of Ciba-Geigy Italy S.p.A. Medical Department.
Keywords
Post menopause
Transdermal replacement therapy